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Cytotoxicity results for gentamicin congeners C1a, C2, and C2a compared to amikacin. (A) CellTiter-Glo luminescent cell viability assay depicts the relative cytotoxicities of gentamicin congeners by quantitation of cellular viability based on ATP-induced luminescence in the presence of increasing aminoglycoside concentrations. (B) Induction of transcription of the Hmox-1 cytotoxicity marker for gentamicin congeners compared to amikacin.
