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Pharmacokinetic data for gentamicin C2 and C2a in rata
| Dose (mg/kg) | AUC (mg/liter × h) |
|
|---|---|---|
| C2 | C2a | |
| 10 | 40 | 30 |
| 30 | 120 | 80 |
| 100 | 330 | 300 |
Repeat measurements were not made to enable a between-experiment statistical analysis, but typical fitting errors for an 8-time-point study to compute values for area under the concentration-time curve (AUC) are higher than the AUC differences observed between C2 and C2a. Plasma protein binding was 84% and 86% unbound for C2 and C2a, respectively.
