Table 3.
List of edible vaccine with their patent/application number.
| Sl. no. | Patent/application number | Patent holders | Clam | References |
|---|---|---|---|---|
| 1. | 6136320 | Prodigene | Production and transfer of recombinant antigen to plant cells through the plasmid-vector system; production of vaccine for hepatitis and transmissible gastroenteritis virus. | https://patents.justia.com/patent/6136320 (accessed on April 2020) |
| 2. | – | Found.Advan. Mil. Med. | Antigen expressed in plant cell, Particularly useful against shigellosis. | [8] |
| 3. | – | Ribozyme-Pharmaceuticals, Inc. | Nucleic acid vaccine for the treatment or prevention of plant or animal viral infection | [8] |
| 4. | – | Rubicon-Lab | Retrovirus expressed in animal or plant cells useful as virus and cancer vaccine. | [8] |
| 5. | 6127145, 6066781 | Applied Phytologics | Gene construction for susceptibility to disease; production of vaccine in rice, wheat, barley and corn. Construction of a vector containing codon-optimized alpha sub 1 antitrypsin sequence and Production of mature protein (alpha-1 antitrypsin) in plant. |
https://patents.justia.com/patent/6127145 (accessed on April 2020) https://patents.justia.com/patent/6066781 (accessed on April 2020) |
| 6. | 5977438 | Biosource (now Large Scale Biology) | Production of a malarial B-cell, cytotoxic T lymphocyte (CTL) in plant as viral coat protein fusion. | https://patents.justia.com/patent/5977438 (accessed on April 2020) |
| 7. | – | University of Yale | Vaccine against invertebrates (insects, helminths, arachnids, etc.) | [8] |
| 8. | – | University of Texas | Produced Hepatitis B virus core antigen for recombinant vaccine production. | [8,63] |
| 9. | – | Biocem; Rhone-Merieux | Transgenic plant used to produce rabies vaccine. | [8] |
| 10. | Institute Pasteur | In gene therapy attenuated E. coli vaccine is used. | [8] | |
| 11. | 6395964 | University of Texas A&M/Tulane University | To boost immunity with the aid of oral administration of antigen and adjuvant with transgenic plant to combat disease like diarrhoea, and cholera. | https://patents.justia.com/patent/6395964 (accessed on April 2020) |
| 12. | 7282625, 20030208792 | Scripps Research Institute | Production of progeny expressing immunoglobulin heavy and immunoglobulin light chain. Isolation of mRNA coding, immunoglobulin heavy and light chain-coding gene in the transgenic plants. TMV modified CP gene produce HIV GP10 V3 loop fusion protein containing the TMV coat protein, and to overproduce peptides and protein. |
https://patents.justia.com/patent/7282625 (accessed on April 2020) https://patents.justia.com/patent/20030208792 (accessed on April 2020) |
| 13. | Cornell University | Increasing foreign protein expression | [58] | |
| 14. | 7422747 6777546 |
University Loma Linda | For the treatment of acute gastroenteritis. Transgenic plant vaccine used to treat autoimmune disease. |
https://patents.justia.com/patent/7422747 (accessed on April 2020) https://patents.justia.com/patent/6777546 (accessed on April 2020) |
| 15. | – | Agr Genet/Purdue Research Foundation | In against of foot and mouth disease, HIV, and human rhino virus modified virus are used for the production of vaccine. | [8] |
| 16. | 10480002 | Transalgae Israel Ltd. | Algal based nervous necrosis viruses (NNV) vaccine for white grouper (Epinephelus aeneus), and European bass fish; Salmonella enterica Serovar enteritidis Flagellin Expressing Algae vaccine for chicken. | https://patents.justia.com/patent/10480002 (accessed on April 2020) |
| 17. | 10617751 | VisionTech International Limited | The recombinant yeast is used as edible vaccine for preventing white spot syndrome virus (WSSV) infection in shrimps. | https://patents.justia.com/patent/10617751 (accessed on April 2020) |
| 18. | 8282936 | Asahi Glass company Ltd. | Edible Human papilloma virus type 16 vaccine is produced by Avirulent fission yeast (Schizosaccharomyces pombe) host. | https://patents.justia.com/patent/8282936 (accessed on April 2020) |
| 19. | 10030250 | Keneth John Piller, Kenneth Lee Bost | Edible vaccine expressed in transgenic soybean used in humans and animals to treat viral, bacterial, fungal, parasitic, or prion related disease, cancer antigens, and toxins. This vaccine can be used to induce tolerance to allergens, and tolerance to autoimmune antigens. | https://patents.justia.com/patent/10030250 (accessed on April 2020) |
| 20. | 7354760 | University of Central Florida Research Foundation, Inc. | Edible vaccine against Bacillus anthracis and Yersina pestis to give immunity in mammals. | https://patents.justia.com/patent/7354760 (accessed on April 2020) |
| 21. | 6777546 | Loma Linda University | CTB-autoantigen chimeric gene construct in plant cells for the development of plant-based vaccine and used in systemic immunosuppressive therapy in autoimmune disease and in transplant. | https://patents.justia.com/patent/6777546 (accessed on April 2020) |
| 22. | 5612487 | Edible Vaccine, Inc. | Edible vaccine to treat viral infection like hepatitis B by using it surface antigen. | https://patents.justia.com/patent/5612487 (accessed on April 2020) |