Table 6.
Probiotic based vaccine.
| Sl. no. | Vehicle | Vaccine target | Antigen | Immune response | Outcome | Reference |
|---|---|---|---|---|---|---|
| 1. | L. lactis | Streptococcus pneumoniae | PppA (LPA+) | Mucosal IgA antibody and serum antibody | Boosted resistance to Intranasal infection with virulent pneumococcal serotypes | [91] |
| 2. | L. lactis | Rotavirus | VP8 | Intestinal IgA antibody and serum antibody | Suppressed the viral infection (100%) in MA-104 cells | [92] |
| 3. | L. lactis | Helicobacter pylori | UreB | Serum antibody and fecal IgA | Protected mice from gastric infection with H. pylori strain SS1. | [93] |
| 4. | L. casei | Porcine epidemic diarrhoea virus (PEDV) | Core neutralizing epitope (COE) | High level of SigA and IgG, and a Th2 immune response | Protected piglets (60%) 96 h post-infection of PEDV | [92] |
| 5. | EcN | Enterotoxigenic Escherichia coli (ETEC) | Stx B-subunits, OspA and OspG proteins | Heterogeneous immune response | Insufficient to mediate protection | [94] |
| 6. | S. gordonii | Bordetella pertussis | S1 subunit of pertussis toxin (PT) | SigA in saliva and IgG | Long-term oral colonization and maintenance of recombinant S. gordonii in BALB/c mice | [95] |
| 7. | B. subtilis | E. coli | LTB | Serum IgG and fecal IgA | 50% protection to mice challenged with ETEC heat labile toxin (LT) | [96] |
| 8. | B. subtilis | Clonorchis sinensis | C. sinensis enolase | A mix of IgG1/IgG2a | Rats immunized have worm reduction rate and egg reduction rate of 61.07% and 80.67% respectively | [96] |