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. Author manuscript; available in PMC: 2020 Sep 3.
Published in final edited form as: Curr Opin Syst Biol. 2019 Sep 11;17:35–40. doi: 10.1016/j.coisb.2019.09.002

Table 1.

Experimental approaches for studying cancer heterogeneity

Technique Cost Number of read-outs per cell Spatial information Temporal information
Single-cell sequencing High 10,000’s No No
seqFISH+ Mid 1,000’s Yes No
cyclicIF, mIHC Low 10’s Yes No
Intravital imaging High 10’s Yes Yes
Reporter molecules Low 1 Yes Yes