Figure 1.

Targeted proteomics accurately differentiates coronavirus disease 2019 positive (COVID19+) ICU patients from healthy control subjects. A, Subjects plotted in 2D following dimensionality reduction of their respective proteomes by stochastic neighbor embedding. Yellow dots represent healthy control subjects, whereas purple dots represent age- and sex-matched COVID19+ ICU patients (ICU day 1 plasma). The dimensionality reduction shows that based on the plasma proteome, the two cohorts are distinct and easily separable (100% classification accuracy). The axes are dimension less. B, Feature classification demonstrating the top 20 plasma proteins that classify coronavirus disease 2019 status with their % association.