Table 2.

Underlying Causes of death in people With epilepsy 1999–2017

All deaths in people with epilepsy			1999	2008	2017	Per cent change	P value
			1613	1786	4131
Rank	Underlying cause of death	ICD-10 codes	Number and proportion of deaths due to the underlying cause
1	Epilepsy	G40–G47	845 (52.39%)	881 (49.33%)	1578 (38.19%)	−27.1%	<0.001
2	Malignant neoplasms	C00–C97	91 (5.64%)	83 (4.64%)	355 (8.59%)	+52.3%	<0.001
3	Cerebrovascular disease	I60–I69	105 (6.51%)	120 (6.72%)	284 (6.87%)	+5.5%	0.62
4	Ischaemic heart disease	I20–I25	174 (10.79%)	123 (6.89%)	256 (6.19%)	−42.6%	<0.001
5	Degenerative diseases of the CNS (ie, Alzheimer’s)	G30–G31	24 (1.49%)	55 (3.08%)	195 (4.72%)	+216.8%	<0.001
6	Cerebral palsy	G80–G83	28 (1.74%)	52 (2.91%)	149 (3.61%)	+107.5%	<0.001
7	Organic mental disorders (vascular dementia and delirium)	F01–F09	16 (0.99%)	35 (1.95%)	127 (3.07%)	+210.1%	<0.001

Data are expressed as the number and proportion of deaths due to the underlying cause, Cochran-Armitage test for trend.

CNS, central nervous system; ICD, International Classification of Diseases.