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. 2020 Aug 26;15(8):e0237646. doi: 10.1371/journal.pone.0237646

Fig 5. CD62L+Bcl6+ tumor-infiltrating cells exhibit cytotoxicity.

Fig 5

(A) Tumor-infiltrating CD62L+ and CD62L- CD8 T cells were sorted from OT-1 mice (CD45.2) that had been transplanted with B16-OVA one week in advance. Sorted cells were then transferred into B16-OVA-transplanted wild-type mice (CD45.1). CD107a expression in tumor-infiltrating CD8 T cells derived from transferred CD62L+ cells (CD45.2+) and host T cells (CD45.2-) were analyzed. One representative analysis of two independent experiments is shown. (B) C57BL/6 mice (6 week-old-female) were subcutaneously transplanted with 1×105 B16-OVA cells. One day later, 1 ×106 OT-1 T cells either from Bcl6+/+ or Bcl6-/- mice that had been activated with 100 pM OVA peptides for 48 h were transferred i.v. and tumor volumes were analyzed on the day indicated after the tumor transplantation. Representative analysis of two independent experiments is shown. PBS was injected as a control. Mean ± SEM; n = 6 (C) Tumor volumes on day 14 in the individual mice are shown. Error bars are Mean ± SEM; n = 6; *P<0.05; **P<0.01.