Fig 2. Inheritance rules for gene drives.

In this example, ‘a1’ is the driven allele and ‘a0’ is the wild-type allele. Red mosquitoes represent mosquitoes with the driven allele ‘a1’ either in the homozygous or heterozygous configuration. Black mosquitoes represent wild-type mosquitoes, which are homozygous in ‘a0’. The drive successfully cleaves the target site 95% of the time. In the event of drive failure, the wild-type allele remains. This is akin to modeling drive failure in terms of the driven allele failing to home in to the target site. This does not include target site resistance through natural mutation or non-homologous end joining (NHEJ). No other mutations are considered. Three mating scenarios are presented: (A) When a drive carrying heterozygous mosquito mates with a homozygous wild-type mosquito, (B) a heterozygous-with-drive mosquito mates with a homozygous-with-drive mosquito, and (C) two heterozygous-with-drive mosquitoes mating.