Fig 3. Seasonality and spatial simulation setup using EMOD.

(A) Single peak seasonality profile characteristic of a Sahelian seasonal and transmission setting. All simulations presented here with a prevalence endpoint measure use this seasonality profile resulting in an annual EIR of around 125 infectious bites per person. (B) Spatial grid used for spatiotemporal gene drive simulations. Six nodes with the largest human population are selected as release sites for genetically modified mosquitoes carrying drives and are marked in red.