Fig 9. Evolution of true prevalence over time when different intervention packages are deployed in a multi location Sahelian setting.

Results are from a spatial simulation with 150 one square kilometer nodes with varying population and larval habitat sizes spread across 300 square kilometers. Four different scenarios are explored—absent any vector control interventions, release of genetically modified mosquitoes carrying a drive that reduces the probability of parasite transmission from mosquitoes to humans, deploying ITNs every three years just as the peak season begins to pick up, and a combination of gene drive and ITNs. The average of 50 stochastic realizations of each scenario is represented by solid lines while the shaded area represents one standard deviation.