Figure 5.

High IL-31Ra expression in breast tumors from patients correlates with IL-2 and IL-4 and contributes to immune modulation and overall survival. (A, B) Pearson correlation analysis was performed on mRNA levels of IL-31Ra relative to IL-2 (A) or IL-4 (B) mRNA levels from Affymetrix data sets of patients with breast cancer. (C) Cell deconvolution was performed on bulk mRNA data set of patients with breast cancer to identify immune subsets present in the tumor microenvironment. The correlation between the different immune cell subsets and IL-31Ra expression was plotted and compared with patients where IL-31Ra expression was not detected. Red indicates positive correlation. Blue indicates negative correlation. (D) Kaplan-Meier curves of patients with breast cancer who received neoadjuvant chemotherapy were plotted as a function of mRNA levels of IL-31Ra, IL-2, and IL-4. IL, interleukin; IL-31Ra, IL-31 receptor A; Treg, T regulatory cells; NK, natural killer; mDCs, myeloid dendritic cells.