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. 2019 Oct 4;116(11):1863–1874. doi: 10.1093/cvr/cvz263

Figure 6.

Figure 6

Jcad knock-out mice have a reduced recovery after hind limb ischaemia. (A) Reduced recovery of plantar perfusion in male Jcad knock out (Jcad−/−) mice after femoral artery ligation compared with wild types (Jcad+/+; *P < 0.05, RM ANOVA). (B) Representative Doppler images of plantar perfusion immediately after and 14 days post-femoral artery ligation (pseudocolor scale, arbitrary units). (C) Loss of Jcad is associated with increased presence of degenerative tissue (defined as hypereosinophilic muscle with no or swollen nuclei and the presence of multiple cellular infiltrate) and a decrease in regenerative tissue (defined as the presence of centralised nuclei) in gastrocnemius muscle 14 days after femoral artery ligation (*P < 0.05, Mann–Whitney). (D) Representative images of injured and un-injured gastrocnemius muscle 14 days after femoral artery ligation, scale bar = 1.5 mm. Data are expressed as the mean ± SEM, each point represent an individual animal, n = 6 per group. Black symbols = Jcad+/+, red symbols = Jcad−/−.