Fig 5. Curves depicting power to detect association under various TWAS scenarios.

The x-axis represents the proportion of phenotypic variance explained by gene expression. As in Fig 4, AA reflects simulated African-Americans constructed from YRI and CEU. The curves represent logistic interpolations of whether or not the causal gene was declared significant in an association test of a phenotype from the testing population with gene expression predicted from a training population into the testing population. Gray areas denote 95% confidence regions of mean power conditional on the effect size.