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. 2020 Aug 26;6(35):eabb5820. doi: 10.1126/sciadv.abb5820

Fig. 2. POLE3 and POLE4 promote the transfer of parental H3-H4 to leading strands in mouse ES cells.

Fig. 2

(A) Snapshots of OK-seq reads density and bias and H4K20me2 and H4K12ac eSPAN reads density and bias in WT, POLE3 KO, and POLE4 KO mouse ES cells at selected initiation zones on chromosome 3. (B and D) Average bias of H4K20me2 (B) and H4K12ac (D) eSPAN (n = 1548) in WT, POLE3 KO, and POLE4 KO mouse ES, each with two repeats. (C and E) Representative heatmap of H4K20me2 (C) and H4K12ac (E) eSPAN biases at each of 1548 initiation zones in POLE3 KO and POLE4 KO mouse ES cells. The initiation zones were ranked from the most efficient (top) to the least efficient (bottom).