Fig. 2. Target tissue distribution of oral PLGA-GA₂-CUR in healthy dogs and anti-inflammatory effects of oral PLGA-GA₂-CUR in a canine model of acute intraocular inflammation.

(A) Aqueous humor levels of CUR following a single oral dose of PLGA-GA₂-CUR. (B to D) Following intracameral injection of lens protein at t = 0 hours, eyes were serially evaluated using the SPOTS system, including measurements of (B) aqueous flare, (C) pupillary light reflex, (D) conjunctival swelling. Statistical significance of oral PLGA-GA₂-CUR administration was compared with treatment with oral carprofen and untreated controls, as determined by a two-way ANOVA. Statistical significance is denoted by *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001.