Fig. 3. Anti-inflammatory effects of topical PLGA-GA₂-CUR in a canine model of acute intraocular inflammation.

(A to C) Following intracameral injection of lens protein at t = 0 hours, eyes were serially evaluated using the SPOTS system, including measurements of (A) aqueous flare, (B) pupillary light reflex, (C) conjunctival swelling. Statistical significance of topical PLA-GA₂-CUR administration was compared to treatment with topical prednisolone acetate and untreated controls, as determined by a two-way ANOVA. Statistical significance is denoted by *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001.