Table 1. Summary of hematology values in healthy dogs before and after oral PLGA-GA2-CUR administration.
WBC, white blood cells; Abs, absolute; Rel, relative; RBC, red blood cell; HGB, hemoglobin; HCT, hematocrit; MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration; RDW, red cell distribution width; PLT, platelet; MPV, mean platelet volume; PCT, procalcitonin; Retic, reticulocyte; Retic abs count, absolute reticulocyte count.
| CBC whole blood | Before dosing | 24 hours after dosing PLGA-GA2-CUR | 7 days after dosing PLGA-GA2-CUR | Reference range |
| Total WBC (K/μl) | 13.46 ± 3 | 10.79 ± 2.35 | 11.5 ± 1.36 | 6.0–17.0 |
| Abs neutrophils (K/μl) | 8.93 ± 2.94 | 6.00 ± 1.4 | 6.98 ± 1.53 | 3.0–11.5 |
| Abs lymphocytes (K/μl) | 3.7 ± 0.46 | 3.95 ± 1.04 | 3.33 ± 0.81 | 1.0–4.8 |
| Abs monocytes (K/μl) | 0.57 ± 0.42 | 0.6 ± 0.29 | 0.9 ± 0.22 | 0.15–1.35 |
| Abs eosinophils (K/μl) | 0.27 ± 0.06 | 0.3 ± 0.1 | 0.25 ± 0.17 | 0.10–1.25 |
| Rel neutrophils (%) | 65.33 ± 6.81 | 55.5 ± 1.29 | 60.5 ± 8.58 | – |
| Rel lymphocytes (%) | 29 ± 9.54 | 36.25 ± 2.87 | 29.25 ± 7.63 | – |
| Rel monocytes (%) | 4.00 ± 3.00 | 6.25 ± 3.77 | 8.00 ± 2.00 | – |
| Rel eosinophils (%) | 3.67 ± 0.58 | 3.46 ± 1.65 | 2.25 ± 1.26 | – |
| RBC (M/μl) | 5.94 ± 0.27 | 8.08 ± 3.76 | 6.54 ± 0.27 | 5.5–8.5 |
| HGB (g/dl) | 10.6 ± 4.81 | 20.35 ± 12.77 | 15.13 ± 0.93 | 12.0–18.0 |
| HCT (%) | 28.1 ± 13.9 | 46.9 ± 13.97 | 43.55 ± 0.86 | 32–55 |
| MCV (fl) | 51.17 ± 16.69 | 54.23 ± 20.69 | 66.68 ± 3.36 | 60–77 |
| MCH (pg) | 35.8 ± 23.13 | 25.6 ± 6.17 | 23.15 ± 0.93 | 19.5–24.5 |
| MCHC (g/dl) | 32.53 ± 7.68 | 29.73 ± 10.49 | 34.73 ± 0.38 | 32–36 |
| RDW (%) | 22.63 ± 13.22 | 15.15 ± 1.5 | 14.63 ± 01.59 | 11.9–14.9 |
| PLT (K/μl) | 445.4 ± 66.72 | 444.33 ± 21.95 | 521.25 ± 79.28 | 200–500 |
| MPV (fl) | 9.00 ± 3.89 | 7.46 ± 5.13 | 9.9 ± 1.75 | 7.9–16.2 |
| PCT (%) | 3.27 ± 4.7 | 0.53 ± 0.2 | 0.52 ± 0.15 | 0.12–0.43 |
| Retic (%) | 0.66 ± 0.34 | 0.94 ± 0.61 | 1.39 ± 0.84 | – |
| Retic abs count (K/μl) | 43.46 ± 14.30 | 41.4 ± 22.7 | 50.66 ± 11.42 | 10–80 |