Table 2. Summary of serum biochemistry values in healthy dogs before and after oral PLGA-GA₂-CUR administration.

GA₂-CUR administration. A/G ratio, albumin-to-globulin ratio; BUN, blood urea nitrogen; ALKP, alkaline phosphatase; AST, aspartate aminotransaminase; ALT, alanine aminotransaminase; GGT, gamma-glutamyl transferase; GLDH, glutamate dehydrogenase.

Chemistry profile	Before dosing	24 hours after dosing PLGA-GA2-CUR	7 days after dosing PLGA-GA2-CUR	Reference range
Total protein (g/dl)	5.33 ± 0.15	5.03 ± 0.10	5.13 ± 0.10	5.6–7.9
Albumin (g/dl)	2.98 ± 0.17	2.93 ± 0.05	3.05 ± 0.06	2.8–4.3
Globulins (g/dl)	2.35 ± 0.19	2.10 ± 0.08	2.08 ± 0.05	1.8–4.2
A/G ratio	1.30 ± 0.18	1.40 ± 0.08	1.48 ± 0.05	0.7–2.5
Calcium (mg/dl)	10.75 ± 0.34	10.48 ± 0.26	10.63 ± 0.13	7.2–12.8
Phosphorus (mg/dl)	7.45 ± 0.70	6.93 ± ±0.54	7.03 ± 0.21	2.3–6.5
Glucose (mg/dl)	73.00 ± 10.30	100.00 ± 6.88	106.25 ± 6.70	60–120
BUN (mg/dl)	14.25 ± 1.26	12.75 ± 1.05	10.25 ± 1.50	8–30
Creatinine (mg/dl)	0.53 ± 0.05	0.58 ± 0.10	0.63 ± 0.05	0.5–1.4
Bilirubin–total (mg/dl)	0.15 ± 0.10	0.20 ± 0.08	0.15 ± 0.06	0.1–0.4
ALKP (U/liter)	108.50 ± 25.72	107.25 ± 16.66	103.50 ± 16.60	12–122
AST (U/liter)	46.25 ± 4.79	35.25 ± 1.50	40.50 ± 2.65	13–52
ALT (U/liter)	34.50 ± 3.70	32.50 ± 5.32	37.75v7.41	13–79
GGT (U/liter)	4.25 ± 1.26	2.50 ± 0.71	3.25 ± 0.50	0–10
GLDH (U/liter)	8.50 ± 1.91	7.75 ± 0.96	6.50 ± 1.29	0–14
Amylase (U/liter)	592.00 ± 93.03	590.00 ± 115.86	605.50 ± 47.76	200–953
Cholesterol (mg/dl)	172.75 ± 18.52	164.50 ± 20.86	160.50 ± 17.71	124–335
Sodium (mEq/liter)	146.75 ± 1.71	145.75 ± 0.50	146.00 ± 1.63	141–156
Potassium (mEq/liter)	5.18 ± 0.38	4.75 ± 0.13	1.93 ± 0.13	3.8–5.5
Chloride (mEq/liter)	107.50v0.58	109.50 ± 0.58	109.50 ± 0.58	109–124
Sodium-to-potassium ratio	28.45 ± 1.83	30.70 ± 0.86	29.65 ± 0.82	–