Table 4. P values of the test ${\mathit{H}}_{\mathbf{0}}\mathbf{:}{\overline{\mathbf{\beta }}}_{\mathbf{3}}\mathbf{=}\mathbf{0}$ using model (2) and ${\mathit{H}}_{\mathbf{0}}^{\prime }\mathbf{:}{\tilde{\mathbf{\beta }}}_{\mathbf{2}}\mathbf{=}\mathbf{0}$ using model (3) for all three comparisons under topical administration.

Pairwise comparison	${\mathit{H}}_{\mathbf{0}}\mathbf{:}{\overline{\mathbf{\beta }}}_{\mathbf{3}}\mathbf{=}\mathbf{0}$	${\mathit{H}}_{\mathbf{0}}^{\prime }\mathbf{:}{\tilde{\mathbf{\beta }}}_{\mathbf{2}}\mathbf{=}\mathbf{0}$
Untreated versus prednisolone acetate	0.11037	0.00438
Untreated versus PLGA-GA2-CUR	0.55748	0.00864
Prednisolone acetate versus PLGA-GA2-CUR	0.18537	0.506844