Table 1. Fabrication parameters optimized to form MB loaded PLGA particles of the intended average diameters.

Parameter	Microparticles	Nanoparticles
Shear Stress	Stir plate (1200 rpm)	1/8” Sonicator Tip (30kHz, ∼25 W)
Polymer Concentration	2 mg/ml	1 mg/ml
Emulsion Volume	90 ml	10 ml
Reactor Volume	200 ml	25 ml
Intended Diameter	2-5 µm	80-100 nm