Table 3. The 25 significantly enriched (α ≤ 0.01) sex-biased Gene Ontology (GO) biological process categories.
| Adj. p value | GO ID | GO Term | No. of genes | Associated differentially expressed genes |
|---|---|---|---|---|
| 5.29E-25 | GO:0044237 | cellular metabolic process | 433 | TRIM25, PEMT, DAZAP2, C1D, SMARCB1, TCF25, BRPF1, DDX18, CHORDC1, RAC1, RMND5A, GTF2F1, RELB, RAB8A, DVL3, RUVBL2, DNMT1, IKBKG, CLCN3, CUL3 |
| 3.75E-16 | GO:0019222 | regulation of metabolic process | 298 | TRIM25, PEMT, DAZAP2, C1D, SMARCB1, TCF25, BRPF1, CHORDC1, RAC1, GTF2F1, RELB, RAB8A, DVL3, RUVBL2, DNMT1, IKBKG, CLCN3, CUL3, MSH6, DNAJB1 |
| 1.27E-16 | GO:0006996 | organelle organization | 200 | SMARCB1, SEC24B, BRPF1, CHORDC1, RAC1, ACP2, RAB8A, RUVBL2, DNMT1, CLCN3, CUL3, LETM1, MSH6, RANBP1, UQCC1, INPP5K, TEP1, KIF5B, CCT4, RALA |
| 1.02E-16 | GO:0051641 | cellular localization | 153 | SEC24B, RAC1, CSE1L, AP2A2, RAB8A, DVL3, RUVBL2, IKBKG, CLCN3, CUL3, LETM1, RANBP1, INPP5K, KIF5B, CCT4, PHAX, PRPF31, RALA, DERL3, UBE2G2 |
| 7.45E-6 | GO:0070887 | cellular response to chemical stimulus | 130 | TRIM25, SMARCB1, RAC1, RAB8A, RUVBL2, DNMT1, CUL3, TBL2, TFAP4, RANBP1, SRA1, INPP5K, KIF5B, HIPK1, GABPA, DERL3, UBE2G2, RNMT, GIT1, DNAJB9, NFE2L2 |
| 2.95E-5 | GO:0035556 | intracellular signal transduction | 116 | TRIM25, RAC1, RELB, DVL3, DNMT1, IKBKG, CUL3, MSH6, TFAP4, INPP5K, STIMATE, HIPK1, GIT1, NFE2L2, DYRK3, MAPKAPK2, BRCA1, SUZ12, ATAD5, CRLF3 |
| 3.88E-3 | GO:0008283 | cell proliferation | 95 | PEMT, SMARCB1, BRPF1, RAC1, DNMT1, TFAP4, SRA1, HIPK1, ODC1, BRCA1, SUZ12, ATAD5, RAB5A, CDK5RAP3, MYDGF, CDK1, PSEN1, CCAR1, RPS6KB1, GGNBP2 |
| 1.53E-6 | GO:0033554 | cellular response to stress | 78 | TRIM25, SMARCB1, CHORDC1, RELB, DVL3, CUL3, TBL2, DNAJB1, TFAP4, HIPK1, DERL3, UBE2G2, DNAJB9, NFE2L2, DYRK3, MAPKAPK2, ATAD5, CDK5RAP3, CDK1, PSEN1 |
| 7.34E-4 | GO:0071417 | cellular response to organonitrogen compound | 23 | RAB8A, DNMT1, GABPA, PSEN1, HSP90B1, OSBPL8, RPS6KB1, SLC6A4, DMTN, RANGAP1, HSF1, PDPK1, ZEB1, PTPN1, PIK3R3, ACTB, BLM, CISH, ATP7A, LEPROT |
| 1.25E-2 | GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 19 | GIT1, MAPKAPK2, PSEN1, OSBPL8, RPS6KB1, PDCD6, DOK2, PDPK1, RABGEF1, PTPN1, PIK3R3, SS18, LMTK2, RBPJ, PRKD2, PIK3R1, NDST1, ERBB2, MAPK1 |
| 4.35E-2 | GO:0030335 | positive regulation of cell migration | 18 | RAC1, MIEN1, RAB5A, CCAR1, RPS6KB1, PDCD6, DMTN, NIPBL, PDPK1, ACTR3, SDCBP, PLAA, FADD, ATP7A, ITGA2B, PRKD2, PIK3R1, HMGB1 |
| 4.13E-4 | GO:0030099 | myeloid cell differentiation | 16 | GABPA, PABPC4, DYRK3, PSEN1, PAFAH1B1, ACIN1, TFRC, SP3, FADD, CUL4A, IREB2, OSTM1, RBPJ, PIK3R1, SOX6, HMGB1 |
| 3.61E-3 | GO:0043583 | ear development | 14 | SEC24B, RAC1, DVL3, MAPKAPK2, ABR, CEP290, PAFAH1B1, TRIP11, NIPBL, SCRIB, ZEB1, MKS1, RBPJ, MAPK1 |
| 9.29E-3 | GO:0072175 | epithelial tube formation | 11 | SEC24B, BRPF1, DVL3, RALA, NUP50, CEP290, HNF1B, SCRIB, IFT57, MKS1, IPMK |
| 1.58E-2 | GO:0043149 | stress fiber assembly | 9 | RAC1, CUL3, INPP5K, RGCC, SORBS3, MKKS, WAS, ARAP1, PIK3R1 |
| 2.85E-5 | GO:0032648 | regulation of interferon-beta production | 9 | POLR3D, RELB, YY1, IFNAR1, RIOK3, IFIH1, POLR3C, TRAF3IP1, HMGB1 |
| 3.79E-2 | GO:0007224 | smoothened signaling pathway | 9 | HIPK1, TROVE2, ULK3, IFT57, STK36, MKS1, TRAF3IP1, NDST1, CENPJ |
| 1.58E-2 | GO:0030038 | contractile actin filament bundle assembly | 9 | RAC1, CUL3, INPP5K, RGCC, SORBS3, MKKS, WAS, ARAP1, PIK3R1 |
| 9.18E-4 | GO:0002066 | columnar/cuboidal epithelial cell development | 8 | SEC24B, RAC1, PAFAH1B1, SCRIB, PDPK1, SIDT2, RFX3, YIPF6 |
| 1.21E-2 | GO:0001738 | morphogenesis of a polarized epithelium | 7 | SEC24B, RAC1, DVL3, PAFAH1B1, MKS1, TRAF3IP1, EXOC5 |
| 8.04E-3 | GO:0060113 | inner ear receptor cell differentiation | 7 | SEC24B, RAC1, PAFAH1B1, TRIP11, SCRIB, MKS1, RBPJ |
| 1.02E-2 | GO:0019080 | viral gene expression | 7 | SMARCB1, TFAP4, INPP5K, DENR, CCNT2, TARDBP, PCBP2 |
| 2.02E-2 | GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | 6 | HIPK1, ATAD5, BAG6, SHISA5, TOPORS, BRCA2 |
| 4.9E-2 | GO:0072577 | endothelial cell apoptotic process | 6 | HIPK1, NFE2L2, RGCC, PDPK1, PAK4, PRKCI |
| 3.47E-2 | GO:0042149 | cellular response to glucose starvation | 5 | TBL2, NFE2L2, HSPA5, SZT2, HIGD1A |
The 25 significantly enriched (α ≤ 0.01) sex-biased Gene Ontology (GO) Biological Process categories with the highest number of DEGs (adjusted p values are provided, GO processes are ranked by number of genes, only the first 20 genes in each category are listed). For a complete list of DEGs and the 116 significant GO terms see S3 and S4 Appendices.