Table 3.
Summary of microscopical findings
Organ | Case 1 79-year-old woman |
Case 2 27-year-old man |
Case 3 70-year-old man |
---|---|---|---|
Lungs |
-Rupture of intra-alveolar septum -Pneumocyte detachment -Hyaline membrane formation -Fibrin deposits in the alveolar spaces -Type II pneumocyte hyperplasia -Focal type II pneumocytes with cytopathic changes -Multinucleated giant cell-like pneumocyte aggregates -Focal areas of rich neutrophilic infiltration -Scattered areas of interstitial lymphocytic inflammatory infiltration |
-Destruction of the alveolar wall lining -Focal presence of hyaline membranes -Intra-alveolar hemorrhage -Large numbers of hemosiderin-laden macrophages within the alveolar space -Mild pneumocyte hyperplasia -Focal type II pneumocytes with cytopathic changes -Multinucleated giant cell-like pneumocyte aggregates -Interstitial, perivascular and peribronchial lymphocytic inflammatory infiltration -Mild vasculitic reaction in some vessel walls -Focal areas of rich neutrophilic infiltration -Microthrombi of the small vessels |
-Detachment of the alveolar lining with scattered pneumocytes within the alveolar space -Moderate type II pneumocyte hyperplasia -Focal type II pneumocytes with cytopathic changes -Mild to moderate lymphocytic inflammatory reaction, more expressed in the perivascular region -Mild vasculitic reaction in some vessel walls -Microthrombi of the small vessels |
Heart |
-Mild to moderate perivascular edema vascular congestion -Areas of small contraction band-like lesions -Small number of scattered lymphocytes between the myocardial fibers |
-Small vessel thrombosis -Marked vascular congestion -Mild edema between the muscle fibers -Myocardial fibers that tend to form contraction bands |
-Myocardosclerosis -Old myocardial infarction -Mild edema -Marked vascular congestion -Acute circulatory disorders |
Kidneys |
-Focal microthrombi formation within the glomerular capillary lumen -Small areas of acute tubular injury with coagulative necrosis |
-Shrunken glomeruli with enlarged Bowman space -Acute tubular necrosis |
|
Liver |
-Centrilobular vascular congestion -Macro-vesicular steatosis -Periportal fibrosis with focal porto-portal and porto-central bridging fibrosis -Mild to moderate lymphocytic infiltrate contained within the portal tract |
-Regenerative nodules porto-portal bridging fibrosis -Scattered lymphocytes within the portal areas |
|
Spleen | -Marked congestion white pulp atrophy absence of lymphoid follicles | -Marked congestion white pulp atrophy absence of lymphoid follicles |