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. 2020 Aug 19;13(8):dmm045021. doi: 10.1242/dmm.045021

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© 2020. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 6. — PPX administration significantly downregulates the Bax/Bcl2 ratio and inhibits cyt-c release and Bax translocation. (A-C) Representative immunoblot intensity indicates the Bax/Bcl2 ratio (A), and cytosolic (B) and mitochondrial (C) Bax and cyt-c. The intensity of the targeted protein bands was normalized to β-actin and COX-IV (also known as COX4I1). ***P<0.001 and **P<0.01 compared with the sham group; ^#P<0.05 and ^##P<0.01 compared with the TBI group; ns, not significant (one-way ANOVA with Tukey's multiple comparisons test). Data are presented as mean±s.d. (n=4).