Table 5.
Association of patient-reported health and lifestyle factors at baseline, with response at follow-up (multiple univariable logistic regression)
| ASAS 20 response |
ASAS 40 response |
ASDAS ≥1.1 reduction |
ASDAS score <2.1 |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Baseline variables | OR | (95% CI) | OR | (95% CI) | OR | (95% CI) | OR | (95% CI) | |
| Smoking | Never | Refer | Ref | Ref | Ref | ||||
| Ex | 0.82 | (0.50, 1.35) | 0.83 | (0.49, 1.40) | 1.01 | (0.57, 1.78) | 0.66 | (0.36, 1.21) | |
| Current – light | 0.64 | (0.29, 1.39) | 0.42 | (0.16, 1.08) | 1.87 | (0.74, 4.76) | 0.30 | (0.10, 0.97) | |
| Current – heavy | 0.71 | (0.36, 1.39) | 0.90 | (0.44, 1.82) | 1.37 | (0.63, 2.95) | 0.72 | (0.32, 1.59) | |
| Alcohol drinking | Current – ≤14 units/week | Ref | Ref | Ref | Ref | ||||
| Never | 0.34 | (0.14, 0.82) | 0.22 | (0.06, 0.74) | 0.89 | (0.35, 2.29) | 0.20 | (0.04, 0.92) | |
| Ex | 0.48 | (0.27, 0.87) | 0.39 | (0.19, 0.80) | 0.41 | (0.20, 0.84) | 0.45 | (0.21, 0.96) | |
| Current – >14 units/week | 1.64 | (0.65, 4.19) | 1.38 | (0.57, 3.32) | 1.27 | (0.45, 3.56) | 1.30 | (0.42, 4.05) | |
| SF-12 – MCS | Per unit increase | 1.03 | (1.01, 1.05) | 1.02 | (1.003, 1.05) | 1.02 | (1.001, 1.05) | 1.06 | (1.04, 1.09) |
| SF-12 – PCS | Per unit increase | 1.03 | (1.01, 1.05) | 1.03 | (1.01, 1.06) | 1.01 | (0.99, 1.04) | 1.07 | (1.03, 1.10) |
| BASDAI | Per unit increase | 0.93 | (0.82, 1.05) | 0.98 | (0.87, 1.11) | 1.16 | (1.01, 1.33) | 0.71 | (0.60, 0.85) |
| ASDAS | Per unit increase | 1.18 | (0.94, 1.48) | 1.40 | (1.10, 1.80) | 2.81 | (2.03, 3.88) | 0.74 | (0.55, 0.99) |
| BASFI | Per unit increase | 0.90 | (0.81, 0.99) | 0.92 | (0.83, 1.02) | 0.99 | (0.90, 1.11) | 0.70 | (0.61, 0.81) |
| BASG | Per unit increase | 0.93 | (0.81, 1.05) | 0.96 | (0.84, 1.10) | 0.98 | (0.85, 1.13) | 0.68 | (0.57, 0.81) |
| ASQoL | Per unit increase | 0.93 | (0.88, 0.98) | 0.95 | (0.90, 0.99) | 0.98 | (0.93, 1.03) | 0.82 | (0.76, 0.88) |
| Fatigue | Per unit increase | 0.94 | (0.89, 1.002) | 0.97 | (0.91, 1.04) | 0.94 | (0.88, 1.01) | 0.87 | (0.80, 0.93) |
| Sleep disturbance | Per unit increase | 1.01 | (0.97, 1.05) | 1.01 | (0.97, 1.05) | 0.99 | (0.96, 1.04) | 0.94 | (0.89, 0.98) |
| Activity impairment | Per unit increase | 0.99 | (0.98, 0.99) | 0.99 | (0.98, 1.004) | 0.99 | (0.98, 1.004) | 0.98 | (0.96, 0.99) |
| HADS anxiety | Per unit increase | 0.93 | (0.88, 0.97) | 0.95 | (0.90, 1.01) | 0.95 | (0.90, 1.01) | 0.87 | (0.81, 0.93) |
| HADS depression | Per unit increase | 0.91 | (0.86, 0.96) | 0.94 | (0.89, 1.001) | 0.95 | (0.89, 1.004) | 0.86 | (0.80, 0.93) |
| Spinal VAS | Per unit increase | 0.97 | (0.88, 1.06) | 1.02 | (0.92, 1.13) | 1.11 | (0.99, 1.24) | 0.84 | (0.74, 0.96) |
Note: italics indicate variable for stepwise model (P < 0.2).
OR: odds ratio; ref: reference category; ASAS: assessment in ankylosing spondylitis; SF-12 MCS: short form 12 mental component score; SF-12 PCS: short form 12 physical component score; BASDAI: Bath ankylosing spondylitis disease activity index; BASFI: Bath ankylosing spondylitis functional index; ASDAS: ankylosing spondylitis disease activity score; BASG: Bath ankylosing spondylitis global score; Bath ankylosing spondylitis metrology index; ASQoL: ankylosing spondylitis quality of life index; HADS: hospital anxiety and depression scale; VAS: visual analogue scale.