Table 1.

Clinical trials studying treatment of patients with obesity and depression

Author (year)	Participants	Objectives	Results	Quality of the study
Kiecolt-Glasser et al. [26] (2015)	N=58 women (38 breast cancer survivors and 20 controls)	To study the impact of daily stressors and major depression over metabolic responses related to obesity in the presence of high-calorie food	Stress and depression alter the metabolic response to rich in fat foods increasing obesity (up to 104 kcal more per meal)	Moderate
Lin et al. [10] (2014)	N=131 (126 of them included in the analysis) patients admitted into acute hospitalization ward diagnosed with major depression	Changes in the Hamilton and functional scale based on body weight and BMI in those patients treated with 20 mg of fluoxetine for 6 weeks	Patients who did not achieve remission had a higher BMI and greater weight before commencing the treatment	Moderate
			High weight and BMI are correlated with a slower improvement in both symptoms and functionality at the end of treatment
Toups et al. [24] (2013)	N=662 patients with chronic or recurrent major depression, randomized into 3 treatment groups (28 weeks duration, with open phase and single blind phase) BMI was measured before and after the treatment	To assess if BMI has any influence over the response to antidepressant treatment or in its comorbidities	Depression in obesity was common (46.2%) compared to the 25.5% of the sample with normal weight	Moderate
			There were no significant differences in the response to treatment in the different groups
			The comorbidities did vary depending on the weight
			BMI is associated with the clinical presentation and the prevalence of comorbidities, but not to the response in antidepressant treatment