Table 1. MIC Values of 9 Antibiotic Drugs Tested on Staphylococcal Periprosthetic Knee Infections for Both Standard Cement and ALBC Groups.
| Group | MIC (µg/mL) | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ampicillin/sulbactam | Clindamycin | Erythromycin | Gentamicin | Oxacillin | Rifampin | Tetracycline | TMP/SMX | Vancomycin | ||||||||||
| Non-ALBC | ||||||||||||||||||
| ≤ 8/4 | S | ≤ 0.25 | S | ≤ 0.25 | S | ≤ 1 | S | ≤ 0.25 | S | ≤ 1 | S | ≤ 1 | S | ≤ 0.5/9.5 | S | 2 | S | |
| ≥ 32 | R | ≥ 8 | R | ≥ 8 | R | ≤ 1 | S | ≥ 8 | R | ≤ 1 | S | 2 | S | ≤ 10 | S | 2 | S | |
| ≤ 8/4 | S | ≤ 0.25 | S | ≤ 0.25 | S | ≤ 1 | S | ≤ 0.25 | S | ≤ 1 | S | ≤ 1 | S | ≤ 0.5/9.5 | S | 1 | S | |
| ≤ 8/4 | S | ≤ 0.25 | S | > 4 | R | > 8 | R | ≤ 0.25 | S | ≤ 1 | S | ≤ 1 | S | > 2/38 | R | 1 | S | |
| ≤ 4 | S | ≤ 0.5 | S | ≤ 0.5 | S | ≤ 2 | S | ≤ 0.25 | S | ≤ 1 | S | ≤ 1 | S | ≤ 10 | S | ≤ 0.5 | S | |
| ≥ 32 | R | ≥ 8 | R | ≥ 8 | R | ≤ 2 | S | ≥ 8 | R | ≤ 1 | S | 2 | S | ≤ 10 | S | 2 | S | |
| ≤ 8/4 | S | ≤ 0.25 | S | ≤ 0.25 | S | ≤ 1 | S | ≤ 0.25 | S | ≤ 1 | S | ≤ 1 | S | ≤ 0.5/9.5 | S | 1 | S | |
| ≤ 4 | S | ≤ 0.5 | S | ≤ 0.5 | S | ≤ 2 | S | 1 | S | ≤ 1 | S | ≤ 1 | S | ≤ 10 | S | 2 | S | |
| ≤ 4 | S | ≤ 0.5 | S | ≥ 8 | R | ≤ 2 | S | 0.5 | S | ≤ 1 | S | ≤ 1 | S | ≤ 10 | S | 2 | S | |
| ALBC | ||||||||||||||||||
| ≤ 8/4 | S | ≤ 0.25 | S | ≤ 0.25 | S | ≤ 1 | S | ≤ 0.25 | S | ≤ 1 | S | ≤ 1 | S | ≤ 0.5/9.5 | S | 1 | S | |
| ≤ 8/4 | S | ≤ 0.25 | S | > 4 | R | ≤ 1 | S | 0.5 | S | ≤ 1 | S | ≤ 1 | S | ≤ 0.5/9.5 | S | 1 | S | |
| ≥ 32 | R | ≤ 0.5 | S | ≥ 8 | R | ≤ 2 | S | ≥ 8 | R | ≤ 1 | S | ≤ 1 | S | 40 | S | 2 | S | |
| ≤ 8/4 | S | ≤ 0.25 | S | ≤ 0.25 | S | ≤ 1 | S | ≤ 0.25 | S | ≤ 1 | S | ≤ 1 | S | ≤ 0.5/9.5 | S | 1 | S | |
| ≤ 8/4 | S | ≤ 0.25 | S | ≤ 0.25 | S | ≤ 1 | S | ≤ 0.25 | S | ≤ 1 | S | ≤ 1 | S | ≤ 0.5/9.5 | S | 1 | S | |
| ≤ 8/4 | S | ≤ 0.25 | S | ≤ 0.25 | S | ≤ 1 | S | > 2 | R | ≤ 1 | S | ≤ 1 | S | ≤ 0.5/9.5 | S | 1 | S | |
| ≤ 8/4 | S | > 4 | R | > 4 | R | ≤ 1 | S | ≤ 0.25 | S | ≤ 1 | S | ≤ 1 | S | ≤ 0.5/9.5 | S | 1 | S | |
| ≤ 8/4 | S | ≤ 0.25 | S | ≤ 0.25 | S | ≤ 1 | S | ≤ 0.25 | S | ≤ 1 | S | ≤ 1 | S | ≤ 0.5/9.5 | S | 1 | S | |
| ≤ 8/4 | S | ≤ 0.25 | S | ≤ 0.25 | S | ≤ 1 | S | ≤ 0.25 | S | ≤ 1 | S | ≤ 1 | S | ≤ 0.5/9.5 | S | 1 | S | |
| ≥ 32 | R | ≥ 8 | R | ≥ 8 | R | ≥ 16 | R | 0.5 | R | ≤ 1 | S | ≤ 1 | S | 160 | R | 2 | S | |
| ≤ 8/4 | S | > 4 | R | > 4 | R | ≤ 1 | S | ≤ 0.25 | S | ≤ 1 | S | ≤ 1 | S | ≤ 0.5/9.5 | S | 1 | S | |
| ≤ 8/4 | S | > 4 | R | ≤ 0.25 | S | ≤ 1 | S | ≤ 0.25 | S | ≤ 1 | S | ≤ 1 | S | ≤ 0.5/9.5 | S | 2 | S | |
| ≤ 8/4 | S | > 4 | R | > 4 | R | ≤ 1 | S | ≤ 0.25 | S | ≤ 1 | S | ≤ 1 | S | ≤ 0.5/9.5 | S | 1 | S | |
| ≤ 8/4 | S | ≤ 0.25 | S | > 4 | R | ≤ 1 | S | ≤ 0.25 | S | ≤ 1 | S | > 8 | R | ≤ 0.5/9.5 | S | 1 | S | |
MIC: minimum inhibitory concentration, ALBC: antibiotic-loaded bone cement, TMP/SMX: Trimethoprim/Sulfamethoxazole, S: susceptibility to an antibiotic, R: resistance to an antibiotic.