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. 2020 Aug 1;10(21):9721–9740. doi: 10.7150/thno.44342

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Knocking down expression of AURKB mediates growth and apoptosis in melanoma cells. A375, A375R, M249, and M249R melanoma cells with stable knockdown of AURKB were established. (A) Knocking down AURKB suppresses A375 and A375R cell growth as determined by an anchorage-independent growth assay. (B) Knocking down expression of AURKB suppresses M249 and M249R cell growth as determined by an anchorage-independent growth assay. Knocking down expression of AURKB induced (C) A375, (D) A375R, (E) M249 and (F) M249R apoptosis rate as shown by flow cytometry analysis. Statistical significance was determined by one-way ANOVA and the asterisks indicate a significant change compared with the control group (***, p < 0.001).