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. 2020 Aug 1;10(21):9721–9740. doi: 10.7150/thno.44342

Figure 4.

Figure 4

AURKB mediates EGF associated BRAF/MEK/ERKs and PI3-K/AKT pathways. (A, B) Knocking down of AURKB suppressed the level of EGF in A375 and A375R tumor from xenograft mice compared with shcontrol. The asterisks indicate a significant difference compared with the shcontrol group (*, p < 0.05; ** p < 0.01). (C) Knocking down of AURKB increased levels of c-PARP, c-caspase 3, and decreased of Bcl-2 level of A375 and A375R cell lines. (D, E) Western blot analysis of activation of BRAF/MEK/ERKs and PI3-K/AKT by knocking down of AURKB in A375 and A375R cell lines.