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. 2020 Aug 1;10(21):9741–9766. doi: 10.7150/thno.46913

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PAK1 structure and the autoactivation mechanism. (A) Schematic representation of the P21-activated kinases including Group I PAKs and Group II PAKs. Of them, PAK1-3 are divvied into Group I PAKs and PAK4-7 are divvied into Group II PAKs. (B) PAK1 contains a p21-binding domain (PBD) at the N-terminus for GTPase association, an auto inhibitory domain (AID) and a C-terminal kinase domain. (C) PAK1 can be activated or inhibited by numerous regulators and inhibitors. (D) The autoactivation mechanism of PAK1 which mainly dependent on phosphorylation.