Figure 3.

Endogenous upstream regulators of PAK1. (A) miRNAs and LncRNAs that involve in regulating the expression of PAK1. Of them, miRNAs target PAK1 or PAK-related proteins to regulate PAK1 expression. Moreover, LncRNAs regulate PAK1 activity via target PAK1-related miRNAs. (B) The protein interaction is another way to regulate PAK1 activity. The proteins can regulate PAK1 activity mainly through phosphorylation, acetylation, transcriptional regulation, and PPI network. The green proteins in the figure inhibit PAK1 activity and the blue proteins activate PAK1 activity.