Figure 4.

PAK1 is a key molecular determinant in major cell proliferation pathways. (A) PAK1 promotes Wnt / β-catenin signaling via activating β-catenin. The activation of β-catenin by PAK1 is mainly through direct phosphorylation and PAK1-AKT-GSK-3β pathway. After activation, β-catenin translocates to the nucleus and activates the transcription of a series of oncogenes, such as MYC and MMPs. (B) PAK1 is at the core of EGFR/HER2/MAPK pathways, and PAK1 precisely regulates EGFR/HER2/MAPK network to regulate cancer cell.