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PAK1 plays a central role in apoptosis and NF-κB pathways. PAK1 can inhibit apoptosis through Raf1 and DLC1 regulated Bim inhibition and Bcl-2 activation. In addition, PAK1 stimulate JNK-IκB-RelA and NIK-IKKα-RelB/p52 pathways to promote inflammation to promote cancer cell proliferation, migration and survival.
