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PAK1 contributes a lot in cell cycle progression. PAK1 triggers cell cycle progression through phosphorylation of some substrate proteins, including AuroraA, Arpc1b, PLK1, histone H3, MORC2, NF-κB and c-Raf. In addition, PAK1 activates Myc to stimulate the activity of CDK2/CyclinE and CDK4/6/CyclinD to promote cell cycle profression. Moreover, PAK1 can regulate tubulin polymerization and polymerization via TCoB and MACK to play a role in cell cycle regulation.
