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PAK1 fine-tuning the PPI network to accelerate cancer EMT and metastasis. PAK1 can activate Wnt/β-catenin, PI3K-AKT, Ras-MAPK, JNK and NF-κB pathways to promote the transcription of twist, snail and slug. These EMT-promoting transcription factors promote the expression of MMPs, while inhibit the expression of epithelial cell specific protein, such as E-cadherin to promote cancer EMT and metastasis.
