Table 2.

PAK1 inhibitors

No.	Comd.	Structure	Classification	PAK1 inhibition activity	References
1	K-252a		ATP-competitive inhibitors	2.4 nM	172
2	KTD606		ATP-competitive inhibitors	4.0 nM	174
3	CEP1347		ATP-competitive inhibitors	2.5 nM	174
4	Staurosporine		ATP-competitive inhibitors	0.75 nM	175
5	Λ-FL172		ATP-competitive inhibitors	130 nM	176
6	(R-1)		ATP-competitive inhibitors	83 nM	177
7	II-11		ATP-competitive inhibitors	1.6 nM	179
8	PF-3758309		ATP-competitive inhibitors	14 nM	180
9	FRAX597		ATP-competitive inhibitors	7.7 nM	186
10	FRAX486		ATP-competitive inhibitors	8.3 nM	187
11	G‑5555		ATP-competitive inhibitors	3.7 nM	188
12	12		ATP-competitive inhibitors	65 nM	189
13	13		ATP-competitive inhibitors	5.0 nM	190
14	14		ATP-competitive inhibitors	5 nM	191
15	15		ATP-competitive inhibitors	288 nM	192
16	G-9791		ATP-competitive inhibitors	Ki=26 nM	193
17	17		ATP-competitive inhibitors	0.73 μM	194
18	OSU-03012		ATP-competitive inhibitors	1.03 μM	195
19	AK963		ATP-competitive inhibitors	-	196
20	ZMF-10		ATP-competitive inhibitors	194 nM	197
21	IPA-3		Allosteric inhibitors	2.5 μM	198
22	22		Allosteric inhibitors	5 nM	199
23	23		Allosteric inhibitors	18 nM	199
24	2-Mc-1,4-NHQ		Allosteric inhibitors	-	200