Table 2.
Blood biochemical features by clinical conditions in 244 patients with COVID-19
| Moderate (n=91) | Severe (n=107) | Critical (n=46) | Ptrend | Normal range | |
|---|---|---|---|---|---|
| White blood cell count (×109/L)a | 5.22 (3.92 - 6.60) | 5.72 (4.01 - 7.34) | 7.85 (4.62 - 10.61) | 0.006 | 3.5-9.5 |
| Lymphocyte count (×109/L)a | 1.29 (0.91 - 1.79) | 0.90 (0.68 - 1.25) | 0.68 (0.49 - 0.95) | <0.001 | 1.1-3.2 |
| Neutrophil count (×109/L)a | 2.93 (2.29 - 4.24) | 3.90 (2.33 - 5.96) | 6.22 (3.68 - 8.97) | <0.001 | 1.8-6.3 |
| CD4 (/μL)a | 510.00 (343.00 - 691.00) | 378.00 (234.00 - 518.00) | 210.50 (159.25 - 349.00) | <0.001 | 404-1612 |
| CD8 (/μL)a | 303.00 (203.00 - 453.00) | 194.00 (120.00 - 273.00) | 119.50 (68.50 - 160.25) | <0.001 | 220-1129 |
| Haemoglobin (g/L)b | 124.92 ± 13.53 | 124.45 ± 16.45 | 129.17 ± 15.75 | 0.17 | 130-175 |
| Platelet count (×109/L)a: | 247.00 (189.00 - 299.50) | 209.00 (157.00 - 274.00) | 221.00 (174.75 - 254.75) | 0.03 | 100-300 |
| <100, No. (%) | 1 (1.10) | 6 (5.61) | 4 (8.70) | 0.09 | |
| ≥100, No. (%) | 90 (98.90) | 101 (94.39) | 42 (91.30) | ||
| C-Reactive Protein (mg/L)a | 10.00 (5.00 - 37.15) | 42.00 (8.75 - 83.10) | 101.45 (54.00 - 173.43) | <0.001 | 0-10 |
| Procalcitonin (ng/mL)a: | 0.04 (0.03 - 0.05) | 0.07 (0.04 - 0.14) | 0.16 (0.09 - 0.32) | <0.001 | <0.1 |
| <0.1, No. (%) | 78 (85.71) | 69 (64.49) | 13 (28.26) | <0.001 | |
| ≥0.1, No. (%) | 13 (14.29) | 38 (35.51) | 33 (71.74) | ||
| CK-MB (ng/ml)a | 0.82 (0.61 - 1.25) | 1.03 (0.73 - 1.56) | 1.58 (0.88 - 2.59) | 0.007 | 0-5 |
| Hs-cTnI (ng/L)a | 6.00 (6.00 - 6.00) | 6.00 (6.00 - 18.00) | 11.00 (6.00 - 56.75) | <0.001 | 0.04 |
| ≤40, No. (%) | 90 (98.90) | 93 (86.92) | 34 (73.91) | <0.001 | |
| >40, No. (%) | 1 (1.10) | 14 (13.08) | 12 (26.09) | ||
| Myoglobin (μg/L) | 34.00 (23.38 - 51.41) | 39.35 (29.21 - 74.19) | 66.37 (43.18 - 109.50) | 0.006 | 0-110 |
| NTpro-BNP (pg/ml) | 67.00 (26.14 - 176.50) | 161.80 (64.52 - 355.18) | 465.00 (195.25 - 993.50) | <0.001 | 0-450 |
| eGFR (ml/min/1.73 m2)a | 96.00 (90.84 - 105.31) | 94.77 (86.63 - 105.72) | 93.31 (78.50 - 101.20) | 0.25 | > 60 |
| Alanine aminotransferase (U/L)a | 23.00 (15.00 - 41.00) | 29.00 (19.00 - 47.50) | 28.50 (20.25 - 48.75) | 0.02 | 9-50 |
| Aspartate aminotransferase (U/L)a | 23.00 (18.00 - 36.00) | 33.00 (22.00 - 45.50) | 42.00 (31.25 - 53.00) | <0.001 | 15-40 |
| ≤ 40 U/L, No. (%) | 74 (81.32) | 73 (68.22) | 22 (47.83) | <0.001 | |
| >40 U/L, No. (%) | 17 (18.68) | 34 (31.78) | 24 (52.17) | ||
| Alkaline phosphatase (U/L)a | 61.00 (51.50 - 72.00) | 65.00 (52.00 - 82.00) | 67.00 (51.00 - 102.25) | 0.34 | 45-125 |
| Gamma glutamyl transpeptidase (U/L)a | 27.00 (15.50 - 45.00) | 31.00 (21.50 - 60.00) | 39.50 (25.00 - 83.00) | <0.001 | 10-60 |
| Total bilirubin (μmol/L)a | 10.40 (8.05 - 14.00) | 11.20 (8.45 - 14.85) | 13.80 (9.25 - 17.20) | 0.07 | 0-23 |
| Conjugated bilirubin (μmol/L)a | 3.50 (2.80 - 5.00) | 4.20 (3.15 - 5.55) | 5.45 (3.80 - 7.38) | 0.009 | 0-8 |
| Serum creatinine (μmol/L)a | 60.00 (51.00 - 70.00) | 64.00 (53.50 - 75.00) | 65.00 (48.25 - 73.75) | 0.79 | 57-97 |
| Random blood glucose (mmol/L)a | 5.40 (4.70 - 6.85) | 5.60 (4.90 - 6.80) | 7.00 (5.53 - 9.43) | 0.01 | <11.1 |
| Potassium (mmol/L)a | 4.00 (3.64 - 4.32) | 3.98 (3.66 - 4.45) | 3.88 (3.47 - 4.36) | 0.83 | 3.5-5.3 |
| Sodium (mmol/L)a | 142.00 (139.00 - 144.00) | 141.00 (137.50 - 144.00) | 138.00 (136.00 - 142.75) | 0.13 | 137-147 |
| Triglyceride (mmol/L)a | 1.24 (0.92 - 1.68) | 1.23 (0.99 - 1.65) | 1.25 (0.97 - 1.95) | 0.37 | 5.2 |
| Total cholesterol (mmol/L)a | 4.12 (3.32 - 4.58) | 3.79 (3.29 - 4.51) | 3.71 (3.18 - 4.08) | 0.03 | 1.7 |
| Creatine kinase (U/L)a | 52.00 (37.50 - 88.00) | 63.00 (39.50 - 105.50) | 69.50 (37.00 - 144.50) | 0.12 | 50-310 |
| Lactate dehydrogenase (U/L)a | 217.00 (182.50 - 275.50) | 317.00 (244.50 - 422.00) | 434.50 (357.00 - 538.50) | <0.001 | 120-250 |
| ≤250, No. (%) | 56 (61.54) | 30 (28.04) | 5 (10.87) | <0.001 | |
| >250, No. (%) | 35 (38.46) | 77 (71.96) | 41 (89.13) |
Values were presented as a median (interquartile range) for continuous variables with a skewed distribution, b mean± standard deviation for continuous variables with a normal distribution, or No. (%) for categorical variables. P for trend was calculated from the linear or logistic regression model after adjustment of age and sex.
Abbreviations: hs-cTnI, high-sensitivity cardiac troponin I; NT-proBNP, pro-B-type natriuretic peptide; and CK-MB, creatinine kinase.