Table 1.

Main pharmacokinetic parameters of SFB after vein injection in SD rats (n=6)

Parameters	Free SFB	MnMSN@SFB	FaPEG-MnMSN@SFB
t1/2 (h)	8.95±2.73	14.99±2.26**	25.53±2.57**##
AUC0-t (µg/mL*h)	54.35±4.58	80.40±7.81**	129.98±14.65**##
Vss (mg/kg)/(µg/mL)	1.91±0.23	2.02±0.23	2.09±0.27
CL (L/kg/h)	0.18±0.01	0.12±0.01**	0.06±0.01**##
MRT (h)	10.51±0.64	17.57±2.20**	32.74±3.74**##

*P < 0.05, **P < 0.01 vs Free SFB group; ^#P < 0.05, ^##P < 0.01 vs MnMSN@SFB group.