Table 1.
Patients' characteristics stratified according to the protein-based signature for distant metastasis (PSDM)
| All | Low-risk | High-risk | P | |
|---|---|---|---|---|
| Total population | 226 (100) | 145 (64.2) | 81 (35.8) | |
| Age | 0.394 | |||
| < 45 years | 124 (54.9) | 76 (52.4) | 48 (59.3) | |
| ≥ 45 years | 102 (45.1) | 69 (47.6) | 33 (40.7) | |
| Gender | 0.481 | |||
| Male | 174 (77.0) | 109 (75.2) | 65 (80.3) | |
| Female | 52 (23.0) | 36 (24.8) | 16 (19.8) | |
| T Stage | 0.551 | |||
| T1 | 7 ( 3.1) | 6 ( 4.1) | 1 ( 1.2) | |
| T2 | 21 ( 9.3) | 15 (10.3) | 6 ( 7.4) | |
| T3 | 144 (63.7) | 90 (62.1) | 54 (66.7) | |
| T4 | 54 (23.9) | 34 (23.5) | 20 (24.7) | |
| N Stage | 0.898 | |||
| N0 | 13 ( 5.8) | 8 ( 5.5) | 5 ( 6.2) | |
| N1 | 98 (43.4) | 63 (43.5) | 35 (43.2) | |
| N2 | 67 (29.6) | 45 (31.0) | 22 (27.1) | |
| N3 | 48 (21.2) | 29 (20.0) | 19 (23.5) | |
| TNM Stage | 0.611 | |||
| III | 132 (58.4) | 87 (60.0) | 45 (55.6) | |
| IVA | 94 (41.6) | 58 (40.0) | 36 (44.4) | |
| EBV DNA load (copies/mL) | 0.207 | |||
| < 2000 | 92 (40.7) | 64 (44.1) | 28 (34.6) | |
| ≥ 2000 | 134 (59.3) | 81 (55.9) | 53 (65.4) | |
| Radiotherapy | 0.300 | |||
| 2D-RT | 4 ( 1.8) | 4 ( 2.8) | 0 ( 0) | |
| 3D-CRT or IMRT | 222 (98.2) | 141 (97.2) | 81 (100) | |
| Chemotherapy | 0.999 | |||
| CCRT ± IC | 211 (93.4) | 135 (93.1) | 76 (93.8) | |
| RT ± IC | 15 ( 6.6) | 10 ( 6.9) | 5 ( 6.2) | |
| Distant Metastasis | < 0.001 | |||
| Yes | 41 (18.1) | 11 ( 7.6) | 30 (37.0) | |
| No | 185 (81.9) | 134 (92.4) | 51 (63.0) | |
| Disease progression | < 0.001 | |||
| Yes | 65 (28.8) | 29 (20.0) | 36 (44.4) | |
| No | 161 (71.2) | 116 (80.0) | 45 (55.6) | |
| Death | < 0.001 | |||
| Yes | 42 (18.6) | 17 (11.7) | 25 (30.9) | |
| No | 184 (81.4) | 128 (88.3) | 56 (69.1) |
Abbreviations: TNM, tumor-node-metastasis.