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. 2020 Aug 2;10(21):9830–9842. doi: 10.7150/thno.45161

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SIX1 activates the HBP pathway and increases O-GlcNAcylation in HCC. BEL7402 and BEL7404 cells were transduced with SIX1 overexpression or knockdown lentivirus, respectively. A The glucose levels were measured in the cell culture media of cells with SIX1 overexpression or knockdown B Glucose uptake levels were determined in the cell line with different SIX1 expressions. C The mRNA levels of GLUT1, HK2 and GFAT1 were analyzed with qPCR in cells with SIX1 overexpression or knockdown. D GLUT1, HK2 and GFAT1 were analyzed by western blotting in cells with SIX1 overexpression or knockdown. E O-GlcNAcylation was analyzed by western blot in HCC cells with SIX1 knockdown or overexpression. (The data were analyzed by Student's t-test (BEL7402) and one-way ANOVA (BEL7404).*p < 0.05, **p < 0.01, ***p < 0.001).