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. 2020 Jul 25;10(21):9579–9590. doi: 10.7150/thno.48954

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This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.

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The pattern of association between TLRmax and glucose transporters were different according to the subgroups based on ImmuneScore. (A) In the immune-poor group, GLUT1 expression showed a positive correlation with TLRmax (r = 0.27, p = 0.04). (B) However, TLRmax showed no correlation with GLUT3 expression in the immune-poor group (r = -0.11, p = n.s.). (C) In immune-rich group, GLUT1 showed a trend of negative correlation with TLRmax, though it did not reach a statistical significance (r = -0.43, p = 0.24). (D) GLUT3 showed a significant positive correlation with TLRmax (r = 0.78, p = 0.01). (E) We propose the association of glucose uptake with immune profiles in TME based on the reciprocal change of glucose metabolism between cancer and immune cells. A schematic diagram shows the overall glucose uptake of tumors mediated by different GLUTs of cancer and immune cells within TME in accordance with the ImmuneScore.