FIGURE 3.

P450 isoform‐selective drug metabolizing enzyme activities in CHIM from the duodenum, jejunum, and ileum of the small intestines from 10 individual donors quantified using isoform‐selective pathways. Each symbol represents activity from CHIM isolated from each of the regions from a single donor. The horizontal bars represent the mean and standard error values of the 10 donors. CYP3A‐1 and CYP3A‐2 represent midazolam 1′‐hydroxylation and testosterone 6‐β hydroxylation activities, respectively. No statistically significant differences were observed among activities from duodenum, jejunum, and ileum