Table 1.
Parameter | Units | Median | 95% CI | Information |
---|---|---|---|---|
(d−1) | 1.26 | [1.24, 1.28] | Estimated | |
1/δE | (d) | 4.6 | 15,26 | |
1/δP | (d) | 2 | 15,26 | |
1/η | (d) | 5 | 52 | |
1/γI | (d) | 14 | 11 | |
1/αI | (d) | 25 | 11 | |
βA/βP | (1) | 0.022 | [0.020, 0.030] | Estimated |
βI/βA | (1) | 1 | 11,12 | |
(1) | 0.89 | [0.87, 0.92] | Estimated | |
(1) | 0.72 | [0.70, 0.73] | Estimated | |
(1) | 0.50 | [0.48, 0.51] | Estimated | |
(1) | 0.038 | [0.025, 0.053] | Estimated | |
Δt0 | (d) | 35 | 11 | |
ω | 1 | 2.42 | [2.33, 2.52] | Estimated |
The posterior distribution of the parameters marked as estimated was sampled through the DREAMZS implementation of the Markov chain Monte Carlo algorithm53. For all estimated parameters, we used uninformative priors within biologically meaningful boundaries. Following our previous application11, we assumed σ = 0.25, rS = 0.5, ζ = 0.45, and rE = rP = rA = rR = rS, whereas rI = rQ = rH = 0. Moreover, γQ = γI = γH, γA = 2γI, and αH = αI.