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. 2020 Aug 26;10:14204. doi: 10.1038/s41598-020-70921-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Kill curves for log-phase growing multi-drug resistant Klebsiella pneumoniae treated with various concentrations of soluble curcumin, vancomycin, and their combination (b) Kill curves for log-phase growing multi-drug resistant Klebsiella pneumoniae treated with various concentrations of soluble curcumin, meropenem and their combination. (c–h) Evaluation of cytotoxicity over HCT116 cells post-treatment. (c) Untreated HCT116 cells at the time of seeding (d) Untreated HCT 116 cells after 48 h (e) HCT116 cells treated with 64 µg/ml ciprofloxacin and 8 µg/ml sCur (f) HCT116 cells treated with 128 µg/ml meropenem and 8 µg/ml sCur (g) HCT116 cells treated with 1,024 µg/ml vancomycin and 8 µg/ml (h) HCT116 cells treated with 100 µg/ml Imatinib [Graph was generated and analyzed using GraphPad 8.0 (San Diego, CA)].