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. 2020 Aug 26;10:14210. doi: 10.1038/s41598-020-71041-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Hydrodynamic force analysis of a cell captured in a filter by immunoaffinity. (A) Top: picture of a cell captured in a filter by immunoaffinity. The cell has a diameter smaller than the filter. Bottom: shear stress distribution on the surface of the cell simulated using COMSOL Multiphysics. (B) Same as (A) except that the cell diameter is the same as the filter. (C) Same as (A) except that the cell diameter is bigger than the filter. (D) The hydrodynamic force experienced by a cell is plotted as a function of the cell size.