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. 2020 Aug 26;10:14205. doi: 10.1038/s41598-020-69907-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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ADSCs influence the migration and invasion of cervical cancer cells. Graph shows the migration ability of HeLa (a), CaSki (b) and SiHa (c) cells cultured without serum and exposed to different chemoattractants including ADSCs, conditioned medium of coculture (Coculture-CM), conditioned medium of ADSCs (ADSC-CM) and NIH3T3 cells. As a control, CC cells were also cultured with DMEM supplemented with 10% FBS or without FBS. The graph shows the relative percentage of the migration capacity of HeLa, CaSki and SiHa cells after 12 h (a–c). The graph represents three biological replicates, error bars are s.d and *p < 0.05. Pictures show a representative image of the migratory CC cells in each condition. (d–f) Figures show the relative percentage of invading HeLa, CaSki and SiHa cells after 12 h of exposure to various chemoattractants. Figures show a representative image of invading cells in each condition. The graph represents three biological replicates, error bars are s.d and *p < 0.05. IPA analysis showing that the main altered transcripts in HeLa cells cultured in presence of ADSCs are involved in migration (g), chemotaxis (h), and invasion (i). The networks show differentially expressed genes regulated by each signaling pathway. The red color indicates the overexpression of the transcripts.