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. 2020 Aug 26;10:14205. doi: 10.1038/s41598-020-69907-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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ADSC increases the CSC population, migration and invasion in an in vivo model. (a) Images show that the migration capacity of SiHa cells increases proportionally with respect to the amount of ADSCs inoculated in zebrafish embryos after 12 h. SiHa cells are shown in green due to they were transfected with a plasmid harboring a GFP gene. The images show a gradual increase in the migration and invasion of cancer cells from the yolk to the tail of embryos due to the presence of ADSCs. The white arrows show the migration areas in the embryo. (b) The table shows the number of cells inoculated in zebrafish embryos and the proportion of tumors formed in each condition. SiHa, SiHa + ADSC, or control cells: ADSC, HaCaT + ADSC, SiHa + HaCaT and SiHa + NIH3T3 were inoculated into zebrafish embryos, and the tumors were monitored every day for 5 days. (c) The graph depicts the frequency of CSC in each condition representing the number of cells injected with respect to the logarithmic fraction of animals without tumors. (d) The table shows the frequency of CSC calculated based on the ELDA software. (e) The images show tumors developed during 5 days in zebrafish embryos inoculated with ADSC, SiHa or SiHa + ADSC cells. Each experiment was repeated at least three times. (f) The table shows the number of cells inoculated in zebrafish embryos and the proportion of tumors formed in embryos injected with CaSki cells or CaSki + ADSCs cells. (g) The table shows the frequency of CSC calculated based on the ELDA software. (h) The graph depicts the frequency of CSC in each condition representing the number of Caski cells injected with respect to the logarithmic fraction of animals without tumors. (i) The images show tumors developed during 5 days in zebrafish embryos inoculated with CaSki or CaSki + ADSC cells.