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. 2020 Aug 26;10:14205. doi: 10.1038/s41598-020-69907-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The NF-Kappa B pathway is the most activated pathway during the coculture of HeLa-ADSC. (a) Heat map shows the main differentially expressed genes in the HeLa cell line cultured in the presence or absence of ADSC. The expression values are represented as colors, where the range of colors (red, pink, light blue, dark blue) represents the range of expression values (high, moderate, low, lowest). (b) Table shows the main phenotypes enriched in HeLa cells due to the presence of ADSCs obtained from a gene set enrichment analysis (GSEA). For each of the phenotypes, the normalized enrichment score (NES) is indicated. (c) Analysis of GSEA showing significant enrichment (NES = 1.61 and an FDR = 0.049) of the TNFα-NF-kappa B signaling pathway in cervical cancer cells due to the presence of ADSCs. (d) The heat map shows the subset of enriched genes involved in the TNFα-NF-kappa B pathway, where most deregulated genes are involved in the noncanonical NF-Kappa B pathway, such as RELB.