Table 1.
GLP1R/Glp1r and GIPR/Gipr expression in β-cells from published scRNAseq datasets
Number of β-cells (% of total) shown for β-cell expressing either, both, or neither incretin receptor.
| Study | Data Source | Platform | Species | β-cell number | GLP1R+ GIPR− | GLP1R− GIPR+ | GLP1R+ GIPR+ | GLP1R− GIP R− |
|---|---|---|---|---|---|---|---|---|
| Baron et al. (18) | GSE84133* | inDrop | Human | 2507 | 187 (7.5%) | 216 (8.6%) | 30 (1.2%) | 2074 (82.7%) |
| Lawlor et al. (12) | GSE86469* | Fluidigm C1 | Human | 258 | 8 (3.1%) | 184 (71.3%) | 48 (18.6%) | 18 (7.0%) |
| Grün et al. (19) | GSE81076* | CEL-Seq | Human | 161 | 24 (14.9%) | 1 (0.6%) | 0 (0%) | 136 (84.5%) |
| Muraro et al. (20) | GSE85241* | CEl-Seq2 | Human | 445 | 132 (29.7%) | 9 (2.0%) | 6 (1.3%) | 298 (67.0%) |
| Segerstolpe et al. (13) | E-MTAB-5061* | Smart-Seq2 | Human | 308 | 100 (32.5%) | 22 (7.1%) | 83 (26.9%) | 103 (33.4%) |
| Xin et al. (21) | GSE114297 | 10 × Genomics | Human | 7361 | 510 (6.9%) | 98 (1.3%) | 10 (0.1%) | 6743 (91.6%) |
| Tabula Muris (22) | Tabula muris github | Smart-Seq2 | Mouse | 449 | 115 (25.6%) | 42 (9.4%) | 254 (56.6%) | 38 (8.5%) |
* The dataset was provided by SeuratData.