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BCL11A drives invasion and metastatic outgrowth by suppressing MBNL1 and is associated with expression of the stem-like splice form of ITGA6 (ITGA6B). Reduced expression relieves repression of MBNL1 and promotes alternative splicing of ITGA6. Inclusion of exon 27 is associated with reduced TNBC invasion in vitro, reduced metastatic outgrowth in mice, and extended overall survival of patients with basal breast cancer.
